Molecular Compatibility for Solid Organ Transplantation

Webinar Overview

Allograft rejection occurs due to differences in the molecular structure of mismatched HLA antigens. Conventional HLA matching does not account for these molecular differences, making it an inadequate predictor of rejection risk. Molecular HLA compatibility serves as a powerful biomarker and should be incorporated into post-transplant risk assessments.

Learning Objectives

By attending this webinar, participants will:

Learning Objectives:

• Understand how primary allo-immune responses are initiated and executed.

• Explore how molecular compatibility can help estimate the risk of primary allo-immune responses.

• Learn how T cell peptide mismatch (PIRCHE-II score) and B cell eplet mismatch contribute to assessing allograft rejection risk.

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