repeat mismatch https://www.ashi-hla.org/forums/posts.aspx?topic=1371446 Sat, 6 Jun 2026 11:54:58 GMT Thu, 20 Jul 2017 16:34:36 GMT Copyright © 2017 American Society for Histocompatibility and Immunogenetics repeat mismatch https://www.ashi-hla.org/forums/posts.aspx?topic=1371446 https://www.ashi-hla.org/forums/posts.aspx?topic=1371446 I would like to know the practice in your lab regarding the listing of previously mismatched antigens as avoids at unos.
For candidates awaiting 2nd or 3rd renal tx:
A) You don't list any previously mismatched antigens as avoids
B) You list all previously mismatched antigens
C) You list previously mismatched antigens that the patient is sensitized to (with SAB MFI above certain cutoff value e.g. 1000 or 2000)
D) others, please describe

If you choose C, what if the antibody was high but decreased to below the cutoff in current serum, or the preliminary crossmatch is negative? Thank you for sharing the information!

Chang Liu, MD PhD
HLA Laboratory, Wash U/Barnes-Jewish Hospital
]]> Thu, 13 Jul 2017 17:43:04 GMT https://www.ashi-hla.org/forums/posts.aspx?topic=1371980 https://www.ashi-hla.org/forums/posts.aspx?topic=1371980 Sat, 15 Jul 2017 21:27:47 GMT https://www.ashi-hla.org/forums/posts.aspx?topic=1372861 https://www.ashi-hla.org/forums/posts.aspx?topic=1372861 1000 (as long as reactivity is clearly positive). ]]> Wed, 19 Jul 2017 22:55:53 GMT https://www.ashi-hla.org/forums/posts.aspx?topic=1372992 https://www.ashi-hla.org/forums/posts.aspx?topic=1372992 1) list previously mismatched antigens that the patient is sensitized to with SAB MFI >1000. It's unlikely that we would removed these as UAs due to concerns for memory.
2) For 2nd regrafts, we avoid the DRB1 mismatches from the first transplant. We feel there is decent data to support avoiding DRs, and centers are very risk-adverse. However, if the patient waits >3 years and doesn't have antibodies to these DR types, we often remove these "protocol UAs".
3) For 3rd/4th regrafts, we avoid A/B/DRB1 of all previous kidneys. The rationale may be more punitive for avoiding the A/B mismatches, and we may remove these after some period of waiting.

We are in Oregon where the wait times are relatively short and the the centers are risk-adverse! ]]> Thu, 20 Jul 2017 17:34:36 GMT