HLA Gene and Haplotype Frequencies in the North American Population: The National Marrow Donor Program Donor Registry1

Motomi Mori, Pli.D.2, Patrick G. Beatty, M.D.3,
Michael Graves, B.S.4, Kenneth M. Boucher, Ph.D.5
Division of Public Health Sciences, Department of Oncological Sciences
and Division of Hematology/Oncology, Department of Internal Medicine
University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, UT 84132
Edgar L. Milford, M.D.6
Renal Division, Department of Medicine,
Brigham and Women's Hospital and Harvard Medical School,
75 Francis Street, Boston, MA 02115

FOOTNOTES

    1. This work was supported by a grant from the National Heart, Lung and Blood Institute (ROl HL56368). Additional support was provided by the National Heart, Lung, Blood Institute subcontract via the National Marrow Donor Program (NO1-HB-17089) and the Huntsman Cancer Institute (Cancer Center Support Grant 5P30 CA 42014).

    2. Corresponding author. Huntsman Cancer Institute, 546 Chipeta Way, Suite 1100, Salt Lake City, Utah 84108; Tel (801)585-5135; Fax (801)585-5357; Email mmori@genetics.utah.edu.

    3. Blood and Marrow Transplant Program, Division of Hematologyloncology, Department of Internal Medicine, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, Utah 84132; Tel (801)585-3229; Fax (801)585-3432; Email Patrick.Beatty@hsc.utah.edu.

    4. Huntsman Cancer Institute, 546 Chipeta Way, Suite 1100, Salt Lake City, Utah 84108; Tel (801)585-5135; Fax (801)585-5357; Email mgraves@genetics.utah.edu.

    5. Huntsman Cancer Institute, 546 Chipeta Way, Suite 1100, Salt Lake City, Utah 84108; Tel (801)585-9544; Fax (801)585-5357; Email kboucher@genetics.utah.edu.

    6 Renal Division, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02167; Tel (617)732-5872; Fax (617)566-6176; Email emilford @bustoffbwh.harvard.edu.

    7 In the current study the numbers of theoretically possible HLA-A, B and HLA-A, B, DR phenotypes were 250,470 and 19,536,660, respectively, because some of the split antigens were collapsed to respective broad antigens (see Table 2).

    8. In the current study the number of theoretically possible HLA-A, -B and HLA-A, -8,-DR haplotypes were 1,081 and 14,053, respectively, because some of the split antigens were collapsed to respective broad antigens (see Table 2) and because additionally haplotype frequencies were estimated for haplotypes containing Ax, Bx and DRx.

TABLES

            1. Estimated gene frequencies (A11 added, 11/2/00)

            2. HLA-A, B haplotypes with their frequencies

            3. HLA-A, B, DR haplotypes with their frequencies

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This page was created on 9-3-97.