5.083333
#89
HUMAN T-CELL LYMPHOTROPIC VIRUSES (HTLVI/II) IN MEXICAN MESTIZOS AND NATIVES: MIXTECO, SERI AND LACANDON. RELATIONSHIP WITH HLA-B*.
Z. Morales , C. Alaez , A. Rodriguez and C. Gorodezky . 1 Dept of Immunol & Immunogenet, InDRE, Mexico City, Mexico .
HTLVI/ HTLVII are human oncoviridae causally associated with adult T cell leukaemia /lymphoma. They are endemic in Central/South-America where they show geographic clustering: HTLVI among native Amerindians (Andean highlands and Brazilian coast); HTLVII predominates in the lowlands, its prevalence in Yucatan, Mexico is 0.3%. The aim of this study was to assess the prevalence of HTLV I/II antibodies in the Mexican Mestizo and in several native groups: Mixteco from Oaxaca, of the southwest (N=55), Seri from Sonora of the northwest (N=102), Lacandon from the jungle of Chiapas in the southeast (N=175) and Mestizo (N=118). We used the Innogenetics INNO-LIA HTLV I/II Score. It allows the detection of HTLV I/II antibodies in serum/plasma. It also differentiates between HTLVI/HTLVII types.The assay uses recombinant/synthetic peptides derived from HTLVI/II immunodominant proteins. The type-specific antigens for HTLV-I (gag p19-I, env gp46-I) and for HTLV-II (env gp46-II) differentiate between types. The intensity of the reaction on the control lines on each strip is the baseline to assign the reactivity for each antigen on that strip. All populations showed negative results except for the Lacandon in whom 1 individual was found positive and 5 were indeterminates (0.03% including the latter). Every individual was typed for DRB1/DQA1/DQB1 and most of them for A*; B*, C* alleles. Interestingly, the 4/6 Lacandon typed for class I loci, shared B*4002. The data are concordant with those found in Latin America. The expectation was to detect HTLVI/II in the Southeast more than in the rest of Mexico, being a tropical area. The relation with class I alleles in them, agrees with the genetic control of humoral response against viruses