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COMPARISON OF ATP LEVELS IN RENAL HIV POSITIVE PATIENTS TO HIV NEGATIVE PATIENTS.
Robert F. McAlack, PhD, Mysore S. Kumar, MD, Michael Heifets, MD and Elizabeth Tecza, BS. Philadelphia PA, USA, Drexel University College of Medicine and Hahnemann University Hospital, 19102, Division of Pathology and Laboratory Medicine; Philadelphia PA, USA, Drexel University College of Medicine and Hahnemann University Hospital, 19102, Surgery and Philadelphia PA, USA, Drexel University College of Medicine and Hahnemann University Hospital, 190102, Medicine/Nephrology.

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End stage renal disease is a complication of HIV infection. Many patients with HIV nephropathy are suited for kidney transplants. With HAART therapy and immuno-suppression for management of rejection these patients will benefit from such transplants. Study patients were seropositive for HIV with no evidence of ARC or AID syndrome with a circulating HIV viral count of less than 200 c/mm of blood.
ATP levels, pre-transplant, were determined comparing our HIV (+) recipient population to our HIV (-) population using the Cylex Immune Cell Function Assay.
Our results show the HIV (-) population of 489 patients, the average ATP level was 268(ng/ml) with a range of 6-903. Of these, 244 were low range(ave 130ng/ml); 215 were moderate range(ave 332 ng/ml) and 30 were high range(654 ng/ml). In comparison, our HIV positive population of 37 patients, the average ATP level was 269(ng/ml) with a range of 38 – 926. Of these 18 were low range (ave 132 ng/ml); 16 were moderate range(ave 315 ng/ml) and 3 were high range(ave 827 ng/ml).
There was no difference between these two populations. However, after transplant the HIV positive population was much more volatile when immunosuppression was added to therapy there was a resulting increase in infectious incidences. The pre-transplant ATP levels were not indicative of this sensitivity. Post-transplant, however, the ATP levels were indicative of this volativity.