Pub Number: 116-P
Title: ASSOCIATION OF IL-10 PROMOTER POLYMORPHISMS WITH PROSTATE CANCER RISK IN AFRICAN- AMERICANS.
Aim: To determine whether IL-10 promoter Single Nucleotide polymorphisms (SNPís) are associated with Prostate cancer(PCa)cases in African-American men. Since genetic susceptibility is an etiological factor in PCa, we hypothesize that sequence variants in the promoter region of the IL-10 gene that regulate pro inflammatory cytokines, may modify individual susceptibility to this disease.
Methods: Four SNPs in the promoter regions with allele frequency differences between Europeans and West Africans were genotyped using pyrosequencing in 538 unrelated men enrolled in a PCa genetic association study at the Howard University Hospital between 2000-2004.
Results: SNP rs12122923 was found to have the strongest association using the dominant (p=0.048) and the log additive (p=0.029) genetic models. rs1800871 was found to be associated with PCa using the log additive model(p=0.057). However, after adjusting for age, both SNPs became insignificantly associated with PCa.
Conclusions: This study showed an association between IL-10 promoter SNP variation and PCa. This supports the hypothesis that genetic variation in the inflammatory process can contribute to prostate cancer susceptibility.
Session: Genetic Polymorphism (MHC/MIC/KIR/Cytokines) – Tuesday, 10/18/11 from 06:00:00 PM to 07:00:00 PM
Authors: Muneer M. Abbas1,2, Tshela M. Mason1, Luicel Ricks-Santi1,3, George E. Bonney1,4, Victor Apprey1,4, Rick Kittles5, Chiledum Ahaghotu6, Georgia M. Dunston1,2.
Institutions: 1The National Human Genome Center, Howard University, Washington, DC, USA; 2Microbiology, Howard University, Washington, DC, USA; 3Cancer Center, Howard University, Washington, DC, USA; 4Community Health and Family Medicine, Howard University, Washington, DC, USA; 5The Institute of Human Genetics, University of Illinois at Chicago, Chicago, IL, USA; 6Urology, Howard University Hospital, Washington, DC, USA.